:root {
  color-scheme: dark;
  --bg: #07111f;
  --panel: #0d1a2e;
  --panel-2: #11243d;
  --panel-3: #f6f9ff;
  --line: rgba(133, 171, 233, 0.24);
  --text: #eef6ff;
  --muted: #aabbd5;
  --ink: #071126;
  --blue: #37a3ff;
  --cyan: #5be7ff;
  --violet: #9a67ff;
  --green: #55e0a6;
  --warn: #f6c85f;
  --red: #ff6b7a;
  --radius: 8px;
  font-family: Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
}

* { box-sizing: border-box; }

html { scroll-behavior: smooth; }

body {
  margin: 0;
  background:
    radial-gradient(circle at 76% 8%, rgba(74, 130, 255, 0.22), transparent 30%),
    linear-gradient(180deg, #051020 0%, #09192d 52%, #f6f9ff 52%, #f6f9ff 100%);
  color: var(--text);
}

button, input, select { font: inherit; }

.app-shell {
  width: min(1220px, calc(100% - 40px));
  margin: 0 auto;
}

.hero {
  min-height: 660px;
  display: grid;
  grid-template-columns: minmax(0, 1.15fr) minmax(330px, 0.85fr);
  gap: 40px;
  align-items: end;
  position: relative;
  padding: 38px 0 28px;
}

.hero::after {
  content: "";
  position: absolute;
  inset: 86px 0 62px 45%;
  border: 1px solid rgba(91, 231, 255, 0.28);
  background:
    linear-gradient(90deg, rgba(55, 163, 255, 0.15), rgba(154, 103, 255, 0.08)),
    repeating-linear-gradient(90deg, transparent 0 38px, rgba(255, 255, 255, 0.045) 39px 40px);
  clip-path: polygon(14% 0, 100% 0, 100% 82%, 78% 100%, 0 100%, 0 18%);
  z-index: -1;
}

.eyebrow {
  margin: 0 0 12px;
  color: var(--cyan);
  font-size: 12px;
  font-weight: 800;
  letter-spacing: .16em;
  text-transform: uppercase;
}

h1, h2, h3, p { margin-top: 0; }

h1 {
  max-width: 760px;
  margin-bottom: 14px;
  font-size: clamp(28px, 4vw, 46px);
  line-height: 1.02;
  letter-spacing: 0;
}

h2 {
  margin-bottom: 10px;
  font-size: clamp(28px, 4vw, 44px);
  line-height: 1.08;
  letter-spacing: 0;
}

h3 { letter-spacing: 0; }

.hero-copy p:not(.eyebrow) {
  max-width: 660px;
  color: var(--muted);
  font-size: 19px;
  line-height: 1.55;
}

.hero-panel {
  border: 1px solid var(--line);
  border-radius: var(--radius);
  background: rgba(7, 17, 31, .72);
  backdrop-filter: blur(20px);
  padding: 28px;
  display: grid;
  gap: 18px;
}

.hero-dynamics-preview {
  grid-column: 1 / -1;
  min-height: 520px;
  border: 1px solid rgba(91, 231, 255, .32);
  border-radius: var(--radius);
  padding: 20px;
  background:
    radial-gradient(circle at 76% 16%, rgba(91, 231, 255, .12), transparent 26%),
    rgba(8, 18, 33, .92);
  box-shadow: 0 30px 90px rgba(0, 0, 0, .32);
}

.hero-dynamics-preview .chart-toolbar {
  align-items: flex-start;
  flex-direction: column;
  margin-bottom: 12px;
}

.hero-toolbar-header {
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: 18px;
  width: 100%;
}

.hero-top-right-controls {
  display: inline-flex;
  align-items: center;
  justify-content: flex-end;
  gap: 10px;
  margin-left: auto;
  white-space: nowrap;
}

.hero-dynamics-preview h3 {
  margin: 0;
  font-size: 22px;
}

.hero-playback-controls {
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  justify-content: flex-start;
  gap: 8px;
  width: 100%;
  max-width: none;
}

.hero-playback-controls label {
  display: flex;
  grid-template-columns: none;
  align-items: center;
  gap: 8px;
  margin: 0;
  color: var(--muted);
  font-size: 13px;
  white-space: nowrap;
  flex: 0 0 auto;
}

.hero-highlight-control {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  margin: 0;
  color: var(--muted);
  font-size: 13px;
  white-space: nowrap;
}

.hero-playback-controls select {
  width: auto;
  min-width: 142px;
  min-height: 34px;
  padding: 0 10px;
}

.hero-playback-controls input[type="range"] {
  width: 116px;
}

.hero-playback-controls .hero-intervention-time-control {
  min-width: 270px;
}

.hero-intervention-time-control input[type="range"] {
  width: 128px;
}

.hero-playback-controls output {
  min-width: 42px;
  color: var(--cyan);
  font-variant-numeric: tabular-nums;
}

.hero-inhibitor-set {
  display: inline-flex;
  flex-wrap: nowrap;
  align-items: center;
  gap: 7px 10px;
  max-width: none;
  margin: 0;
  padding: 8px 10px;
  border: 1px solid rgba(133, 171, 233, .24);
  border-radius: 8px;
  background: rgba(255,255,255,.035);
}

.hero-inhibitor-set legend {
  padding: 0 5px;
  color: var(--muted);
  font-size: 12px;
}

.hero-inhibitor-set label {
  display: inline-flex;
  align-items: center;
  gap: 5px;
  margin: 0;
  color: var(--text);
  font-size: 12px;
}

.hero-inhibitor-set input {
  width: auto;
}

.hero-icon-actions {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  white-space: nowrap;
}

.hero-icon-actions .icon-button {
  width: 38px;
  min-width: 38px;
  height: 38px;
  min-height: 38px;
  padding: 0;
  display: inline-grid;
  place-items: center;
  font-size: 17px;
  line-height: 1;
}

.hero-dynamics-chart {
  min-height: 430px;
  border: 1px solid rgba(133, 171, 233, .24);
  border-radius: var(--radius);
  overflow: hidden;
  background: #0b1628;
}

.hero-time-readout {
  margin-top: 10px;
  color: var(--muted);
  font-size: 13px;
  text-align: right;
}

.hero-time-readout strong {
  color: var(--cyan);
  font-variant-numeric: tabular-nums;
}

.organ-impact-twin {
  display: grid;
  grid-template-columns: 1fr;
  gap: 16px;
  margin-top: 16px;
}

.organ-body-panel,
.organ-impact-panel {
  min-width: 0;
  border: 1px solid rgba(133, 171, 233, .24);
  border-radius: var(--radius);
  background: rgba(5, 13, 25, .72);
  padding: 18px;
  overflow: visible;
}

.organ-impact-twin.microstructure-active .organ-body-panel {
  display: none;
}

.organ-impact-twin.microstructure-active .organ-impact-panel {
  padding: 0;
  border-color: rgba(91, 231, 255, .24);
  background: transparent;
}

.organ-impact-twin.microstructure-active .organ-panel-header {
  display: none;
}

.organ-impact-twin.microstructure-active .microstructure-comparison {
  min-height: 500px;
}

.organ-body-panel h3 {
  margin: 0 0 12px;
  font-size: 18px;
}

.human-twin {
  display: grid;
  place-items: center;
  min-height: 500px;
}

.human-outline {
  position: relative;
  width: min(360px, 100%);
  aspect-ratio: 2 / 3;
  height: auto;
  border-radius: 12px;
  border: 0;
  box-shadow: none;
  overflow: visible;
  background: #021126;
}

.human-outline img {
  position: absolute;
  inset: 0;
  width: 100%;
  height: 100%;
  object-fit: cover;
  filter: saturate(1.12) contrast(1.04);
  border-radius: 12px;
}

.human-outline::before {
  content: "";
  position: absolute;
  inset: 0;
  z-index: 1;
  background: radial-gradient(circle at 50% 45%, transparent 25%, rgba(1, 9, 24, .12) 58%, rgba(1, 9, 24, .28));
  border-radius: 12px;
  pointer-events: none;
}

.organ-pulse-layer {
  position: absolute;
  inset: 0;
  z-index: 2;
  pointer-events: none;
}

.organ-zone {
  --organ-color: #38bdf8;
  position: absolute;
  border-radius: 999px;
  background: radial-gradient(circle, color-mix(in srgb, var(--organ-color), transparent 12%), color-mix(in srgb, var(--organ-color), transparent 78%) 45%, transparent 72%);
  mix-blend-mode: screen;
  opacity: .72;
  filter: blur(2px);
}

.organ-zone.brain { top: 8%; left: 46%; width: 8%; height: 11%; }
.organ-zone.lung { top: 22%; left: 39%; width: 22%; height: 13%; }
.organ-zone.blood { top: 21%; left: 47%; width: 10%; height: 11%; }
.organ-zone.blood {
  animation: heartOrganBeat var(--heartbeat-speed, .82s) ease-in-out infinite;
  transform-origin: 50% 58%;
}
.organ-zone.liver { top: 34%; left: 36%; width: 18%; height: 9%; }
.organ-zone.kidney { top: 42%; left: 38%; width: 24%; height: 11%; }
.organ-zone.retina { top: 7%; left: 50%; width: 4%; height: 3%; }
.organ-zone.vessels { top: 58%; left: 42%; width: 16%; height: 22%; }
.organ-zone.skin { top: 20%; left: 26%; width: 48%; height: 56%; opacity: .20; }

.heartbeat-monitor {
  --heart-color: #38bdf8;
  position: absolute;
  top: 4.8%;
  left: -51%;
  z-index: 4;
  width: 42%;
  min-width: 180px;
  border: 1px solid rgba(91, 231, 255, .24);
  border-radius: 8px;
  padding: 9px 10px;
  background: rgba(2, 13, 31, .38);
  box-shadow: inset 0 0 20px rgba(91, 231, 255, .08);
}

.heart-rate {
  display: flex;
  align-items: baseline;
  gap: 6px;
  color: var(--heart-color);
}

.heart-rate span {
  font-size: 20px;
  animation: heartbeat var(--heartbeat-speed, .82s) ease-in-out infinite;
}

.heart-rate strong {
  font-size: 25px;
  line-height: 1;
}

.heart-rate em {
  font-style: normal;
  font-size: 11px;
}

.vital-sign-readouts {
  display: grid;
  gap: 3px;
  margin-top: 7px;
  padding-top: 6px;
  border-top: 1px solid rgba(91, 231, 255, .16);
}

.vital-sign-row {
  display: grid;
  grid-template-columns: 25px minmax(58px, auto) 1fr;
  align-items: baseline;
  gap: 5px;
  color: #b8c9e7;
  font-variant-numeric: tabular-nums;
}

.vital-sign-row span {
  color: #69d9ff;
  font-size: 10px;
  font-weight: 800;
  letter-spacing: 0;
}

.vital-sign-row strong {
  color: #eef7ff;
  font-size: 16px;
  line-height: 1.1;
}

.vital-sign-row em {
  font-style: normal;
  font-size: 9px;
}

.heartbeat-monitor[data-bp-state="low"] .blood-pressure-row strong,
.heartbeat-monitor[data-bp-state="high"] .blood-pressure-row strong,
.heartbeat-monitor[data-rr-state="low"] .respiratory-rate-row strong,
.heartbeat-monitor[data-rr-state="high"] .respiratory-rate-row strong {
  color: #fbbf24;
}

.ecg-viewport {
  width: 100%;
  height: 42px;
  margin-top: 7px;
  overflow: hidden;
}

.ecg-track {
  display: flex;
  width: 200%;
  height: 100%;
  animation: ecgScroll var(--ecg-speed, 1.45s) linear infinite;
}

.ecg-wave {
  display: block;
  width: 50%;
  height: 42px;
  flex: 0 0 50%;
}

.ecg-wave polyline {
  fill: none;
  stroke: var(--heart-color);
  stroke-width: 2;
  stroke-linecap: round;
  stroke-linejoin: round;
  filter: drop-shadow(0 0 6px var(--heart-color));
}

.human-outline .organ-hotspot {
  z-index: 5;
}

.organ-hotspot {
  --organ-color: #2f7dff;
  position: absolute;
  z-index: 1;
  width: 15px;
  min-width: 15px;
  height: 15px;
  min-height: 15px;
  padding: 0;
  border: 1px solid color-mix(in srgb, var(--organ-color), white 52%);
  border-radius: 50%;
  color: #f8fbff;
  background: var(--organ-color);
  box-shadow: 0 0 16px var(--organ-color), 0 0 28px color-mix(in srgb, var(--organ-color), transparent 38%);
  font-size: 0;
  cursor: pointer;
  overflow: visible;
}

.organ-hotspot::before {
  content: "";
  position: absolute;
  left: 13px;
  top: 50%;
  width: var(--line-width, 160px);
  height: 1px;
  background: linear-gradient(90deg, var(--organ-color), rgba(91, 231, 255, .08));
  box-shadow: 0 0 8px var(--organ-color);
  cursor: pointer;
}

.organ-hotspot::after {
  content: attr(data-label) "  " attr(data-score);
  position: absolute;
  left: calc(15px + var(--line-width, 160px));
  top: 50%;
  min-width: 132px;
  transform: translateY(-50%);
  border: 1px solid color-mix(in srgb, var(--organ-color), transparent 34%);
  border-radius: 8px;
  padding: 5px 8px;
  color: #f8fbff;
  background: rgba(4, 19, 48, .70);
  box-shadow: inset 0 0 16px rgba(91, 231, 255, .08), 0 0 16px color-mix(in srgb, var(--organ-color), transparent 64%);
  font-size: 11px;
  font-weight: 800;
  white-space: nowrap;
  cursor: pointer;
}

.organ-hotspot.brain { top: calc(4.8% - 10px); left: 50.2%; --line-width: 184px; }
.organ-hotspot.retina { top: calc(9.4% - 15px); left: 51.4%; --line-width: 180px; }
.organ-hotspot.lung { top: 21.6%; left: 56%; --line-width: 163px; }
.organ-hotspot.blood { top: calc(27.8% - 5px); left: 51.6%; --line-width: 179px; }
.organ-hotspot.liver { top: calc(36.8% - 25px); left: 41.2%; --line-width: 216px; }
.organ-hotspot.kidney { top: calc(42.2% - 25px); left: calc(58% - 8px); --line-width: 164px; }
.organ-hotspot.skin { top: 53%; left: 63%; --line-width: 138px; }
.organ-hotspot.vessels { top: 72.5%; left: calc(50.6% + 6px); --line-width: 177px; }

.organ-impact-twin.amd-focus-mode .organ-hotspot::after {
  display: none;
}

.organ-impact-twin.amd-focus-mode .organ-hotspot:not(.retina) {
  opacity: .32;
}

.organ-impact-twin.amd-focus-mode .organ-hotspot.retina {
  width: 18px;
  height: 18px;
  min-width: 18px;
  min-height: 18px;
  box-shadow: 0 0 18px var(--organ-color), 0 0 42px var(--organ-color);
}

.amd-dashboard {
  margin-top: 18px;
  border: 1px solid rgba(91, 231, 255, .24);
  border-radius: var(--radius);
  padding: 20px;
  background:
    radial-gradient(circle at 18% 10%, rgba(56, 189, 248, .15), transparent 30%),
    linear-gradient(135deg, rgba(5, 15, 34, .96), rgba(13, 26, 46, .88));
}

.amd-dashboard[hidden] {
  display: none;
}

.amd-dashboard-header {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 16px;
  margin-bottom: 16px;
}

.amd-dashboard-header h3 {
  margin: 0;
  font-size: 24px;
}

.amd-context-note {
  max-width: 780px;
  margin: 8px 0 0;
  color: var(--muted);
  line-height: 1.55;
}

.amd-dashboard-header strong {
  min-width: 96px;
  border: 1px solid rgba(91, 231, 255, .36);
  border-radius: 8px;
  padding: 10px 12px;
  color: #fff;
  background: rgba(56, 189, 248, .15);
  text-align: center;
  font-size: 22px;
}

.amd-dashboard-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 12px;
}

.amd-panel {
  border: 1px solid rgba(133, 171, 233, .18);
  border-radius: 10px;
  padding: 15px;
  background: rgba(255, 255, 255, .045);
}

.amd-wide-panel {
  grid-column: 1 / -1;
}

.amd-panel h4 {
  margin: 0 0 12px;
  color: white;
  font-size: 15px;
}

.amd-chip-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 8px;
}

.amd-chip-grid span,
.amd-output-card,
.amd-system-row {
  border: 1px solid rgba(91, 231, 255, .16);
  border-radius: 8px;
  background: rgba(3, 12, 28, .45);
}

.amd-chip-grid span {
  display: grid;
  gap: 4px;
  min-height: 58px;
  padding: 10px;
}

.amd-chip-grid strong,
.amd-system-row strong {
  color: #f8fbff;
  font-size: 13px;
}

.amd-chip-grid em,
.amd-system-row span,
.amd-output-card span {
  color: var(--muted);
  font-style: normal;
  font-size: 12px;
  line-height: 1.35;
}

.amd-panel ul {
  display: grid;
  gap: 8px;
  margin: 0;
  padding-left: 18px;
  color: var(--muted);
  line-height: 1.45;
}

.amd-system-list,
.amd-output-grid {
  display: grid;
  gap: 8px;
}

.amd-system-row {
  display: grid;
  gap: 6px;
  padding: 10px;
}

.amd-system-row i,
.amd-output-card i {
  display: block;
  height: 5px;
  width: var(--score-width);
  border-radius: 999px;
  background: linear-gradient(90deg, var(--blue), var(--cyan));
}

.amd-output-grid {
  grid-template-columns: repeat(3, minmax(0, 1fr));
}

.amd-output-card {
  display: grid;
  gap: 6px;
  padding: 10px;
}

.amd-output-card strong {
  color: white;
  font-size: 20px;
  line-height: 1;
}

.amd-calibration-priors {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 10px;
  margin-top: 12px;
}

.candidate-calibration-note {
  margin: 10px 0 0;
  color: var(--muted);
  font-size: 12px;
  line-height: 1.5;
}

.candidate-calibration-review {
  margin: 10px 0;
  color: var(--muted);
  font-size: 12px;
  line-height: 1.5;
}

.candidate-calibration-review.has-conflicts {
  color: #ffb4a8;
}

.candidate-calibration-review + .secondary-button {
  margin-bottom: 10px;
}

.secondary-button {
  min-height: 36px;
  padding: 0 12px;
  border: 1px solid rgba(91, 231, 255, .35);
  border-radius: 7px;
  background: rgba(91, 231, 255, .08);
  color: #dff8ff;
  cursor: pointer;
  font-size: 12px;
  font-weight: 800;
}

.secondary-button:hover,
.secondary-button:focus-visible {
  border-color: var(--cyan);
  background: rgba(91, 231, 255, .16);
}

.candidate-card {
  border-color: rgba(255, 190, 92, .28);
}

.amd-prior-card,
.amd-evidence-card {
  border: 1px solid rgba(91, 231, 255, .16);
  border-radius: 8px;
  padding: 12px;
  background: rgba(3, 12, 28, .45);
}

.amd-prior-card header {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 10px;
  margin-bottom: 10px;
}

.amd-prior-card strong,
.amd-evidence-card strong {
  color: #f8fbff;
  font-size: 13px;
}

.amd-prior-card header span {
  color: var(--cyan);
  font-size: 11px;
  white-space: nowrap;
}

.amd-prior-range {
  position: relative;
  height: 8px;
  margin-bottom: 10px;
  border-radius: 999px;
  background: rgba(255,255,255,.08);
}

.amd-prior-range i,
.amd-prior-range b {
  position: absolute;
  top: 0;
  height: 100%;
  border-radius: inherit;
}

.amd-prior-range i {
  background: linear-gradient(90deg, var(--blue), var(--cyan));
  box-shadow: 0 0 14px rgba(91, 231, 255, .32);
}

.amd-prior-range b {
  width: 3px;
  background: #fff;
  box-shadow: 0 0 10px #fff;
}

.amd-prior-card p,
.amd-prior-card em,
.amd-prior-card small,
.amd-evidence-card p {
  display: block;
  margin: 7px 0 0;
  color: var(--muted);
  font-style: normal;
  font-size: 12px;
  line-height: 1.4;
}

.amd-prior-card p span {
  color: var(--cyan);
}

.amd-evidence-details {
  margin-top: 14px;
}

.amd-evidence-details summary {
  color: #f8fbff;
  cursor: pointer;
  font-weight: 800;
}

.amd-evidence-records {
  display: grid;
  gap: 8px;
  margin-top: 10px;
}

.amd-evidence-card div {
  display: flex;
  flex-wrap: wrap;
  gap: 6px;
  margin-top: 8px;
}

.amd-evidence-card span {
  border: 1px solid rgba(91, 231, 255, .16);
  border-radius: 999px;
  padding: 4px 8px;
  color: var(--muted);
  font-size: 11px;
}

.amd-summary,
.amd-disclaimer,
#amd-drug-summary {
  margin: 0;
  color: var(--muted);
  line-height: 1.55;
}

#amd-drug-summary {
  color: #dbeafe;
}

.amd-disclaimer {
  margin-top: 10px;
  color: #facc15;
  font-size: 12px;
}

@keyframes heartbeat {
  0%, 100% { transform: scale(1); filter: drop-shadow(0 0 2px var(--heart-color)); }
  18% { transform: scale(1.22); filter: drop-shadow(0 0 9px var(--heart-color)); }
  32% { transform: scale(.96); }
  48% { transform: scale(1.12); }
}

@keyframes heartOrganBeat {
  0%, 100% { transform: scale(1); opacity: .68; filter: blur(2px) drop-shadow(0 0 5px var(--heart-color)); }
  18% { transform: scale(1.18); opacity: .95; filter: blur(2px) drop-shadow(0 0 16px var(--heart-color)); }
  34% { transform: scale(.98); opacity: .72; }
  52% { transform: scale(1.08); opacity: .86; }
}

@keyframes ecgScroll {
  from { transform: translateX(0); }
  to { transform: translateX(-50%); }
}

.organ-impact-panel {
  display: grid;
  gap: 12px;
}

.organ-panel-header {
  display: flex;
  justify-content: space-between;
  gap: 12px;
  color: var(--muted);
  font-size: 13px;
}

.organ-panel-header strong {
  color: var(--cyan);
  font-variant-numeric: tabular-nums;
}

.organ-impact-cards {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 10px;
}

.amd-organ-signal-group {
  grid-column: 1 / -1;
}

.amd-organ-signal-group h4,
.amd-secondary-details summary {
  margin: 0 0 10px;
  color: #f8fbff;
  font-size: 13px;
}

.amd-secondary-details summary {
  cursor: pointer;
}

.organ-impact-cards-inner {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 10px;
}

.organ-impact-card {
  border: 1px solid rgba(133, 171, 233, .18);
  border-radius: 10px;
  padding: 12px;
  background: rgba(255,255,255,.04);
}

.organ-impact-card header {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 8px;
  margin-bottom: 8px;
}

.organ-impact-card strong {
  font-size: 14px;
}

.organ-impact-card span {
  color: var(--muted);
  font-size: 12px;
  font-variant-numeric: tabular-nums;
}

.organ-score-bar {
  height: 7px;
  overflow: hidden;
  border-radius: 999px;
  background: rgba(255,255,255,.08);
}

.organ-score-bar i {
  display: block;
  height: 100%;
  width: var(--score-width);
  border-radius: inherit;
  background: var(--organ-color);
  box-shadow: 0 0 18px color-mix(in srgb, var(--organ-color), transparent 36%);
}

.organ-impact-card p {
  margin: 8px 0 0;
  color: var(--muted);
  font-size: 12px;
  line-height: 1.45;
}

.organ-impact-summary {
  margin: 0;
  color: var(--muted);
  line-height: 1.55;
}

.microstructure-comparison {
  margin-top: 0;
  padding: 18px;
  border: 1px solid rgba(133, 171, 233, .24);
  border-radius: var(--radius);
  background: rgba(5, 13, 25, .72);
}

.microstructure-header {
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: 16px;
  margin-bottom: 14px;
}

.microstructure-header h3 { margin: 0; font-size: 18px; }
.microstructure-comparison[hidden] { display: none; }
.microstructure-header-actions { display: flex; align-items: flex-end; gap: 12px; }
.microstructure-header-actions > span { color: var(--cyan); font-size: 12px; white-space: nowrap; }
.microstructure-back { min-height: 32px; padding: 6px 10px; font-size: 11px; white-space: nowrap; }
.microstructure-panels { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 12px; }
.microstructure-panel { min-width: 0; padding: 12px; border: 1px solid rgba(133, 171, 233, .2); border-radius: 8px; background: rgba(2, 13, 31, .6); }
.microstructure-panel header { display: flex; justify-content: space-between; gap: 10px; color: var(--text); font-size: 12px; }
.microstructure-panel header span { color: var(--muted); font-size: 11px; }
.microstructure-panel p { margin: 10px 0 0; color: var(--muted); font-size: 11px; line-height: 1.5; }
.microstructure-visual {
  position: relative;
  min-height: 260px;
  margin-top: 10px;
  overflow: hidden;
  border: 1px solid rgba(91, 231, 255, .16);
  border-radius: 6px;
  background-color: #020916;
}
.tissue-image-crop {
  aspect-ratio: 1 / 1;
  background-image: var(--tissue-image);
  background-repeat: no-repeat;
  background-size: 200% 100%;
  box-shadow: inset 0 0 24px rgba(2, 9, 22, .18);
}
.normal-tissue-image { background-position: left center; }
.impact-tissue-image { background-position: right center; }
.microstructure-evidence {
  grid-column: 1 / -1;
  display: grid;
  gap: 6px;
  padding: 11px 12px;
  border: 1px solid rgba(91, 231, 255, .14);
  border-radius: 7px;
  color: #8fa8ca;
  background: rgba(3, 14, 31, .72);
  font-size: 11px;
  line-height: 1.5;
}
.microstructure-evidence strong { color: #c9d8ed; }
.microstructure-source-links { display: flex; flex-wrap: wrap; gap: 8px; }
.microstructure-source-links a { color: var(--cyan); text-underline-offset: 3px; }
.microstructure-disclaimer { margin: 12px 0 0; color: #7f98bd; font-size: 11px; }
.organ-impact-card[role="button"] { cursor: pointer; }
.organ-impact-card.no-tissue-model { cursor: default; }
.organ-impact-cards[hidden], .organ-impact-summary[hidden] { display: none; }
.organ-impact-card[role="button"]:hover, .organ-impact-card[role="button"]:focus-visible { border-color: var(--organ-color); outline: none; box-shadow: 0 0 0 2px color-mix(in srgb, var(--organ-color), transparent 68%); }

@media (max-width: 760px) {
  .microstructure-header { flex-direction: column; }
  .microstructure-header-actions { width: 100%; align-items: flex-start; flex-direction: column; }
  .microstructure-panels { grid-template-columns: 1fr; }
  .microstructure-evidence { grid-column: 1; }
  .microstructure-visual { min-height: 220px; }
}

.panel-line {
  height: 6px;
  border-radius: 10px;
  background: linear-gradient(90deg, var(--blue), var(--cyan), var(--violet));
}

.hero-stat {
  display: grid;
  grid-template-columns: 92px 1fr;
  align-items: center;
  gap: 18px;
  border-top: 1px solid var(--line);
  padding-top: 18px;
}

.hero-stat strong {
  font-size: 42px;
  line-height: 1;
}

.hero-stat span {
  color: var(--muted);
  line-height: 1.45;
}

.section-nav {
  position: sticky;
  top: 0;
  z-index: 5;
  display: flex;
  gap: 8px;
  overflow-x: auto;
  padding: 12px;
  margin-bottom: 22px;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  background: rgba(7, 17, 31, .88);
  backdrop-filter: blur(18px);
}

.section-nav a {
  flex: 0 0 auto;
  color: var(--text);
  text-decoration: none;
  padding: 10px 14px;
  border-radius: 6px;
}

.section-nav a:hover { background: rgba(255, 255, 255, .08); }

.section {
  margin: 26px 0;
  padding: 38px;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  background: rgba(13, 26, 46, .92);
  box-shadow: 0 24px 70px rgba(0, 0, 0, .24);
}

.experiment-workspace {
  position: relative;
  overflow: hidden;
  background:
    linear-gradient(120deg, rgba(24, 105, 184, .12), transparent 48%),
    rgba(8, 21, 39, .96);
}

.experiment-workspace::before {
  content: "";
  position: absolute;
  inset: 0 0 auto;
  height: 2px;
  background: linear-gradient(90deg, var(--cyan), var(--blue), var(--violet));
}

.experiment-workspace-heading {
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: 24px;
}

.experiment-workspace-heading h2 {
  max-width: 760px;
  margin: 0 0 8px;
  font-size: 26px;
}

.experiment-workspace-heading p:not(.eyebrow) {
  max-width: 780px;
  margin: 0;
  color: var(--muted);
  line-height: 1.6;
}

.local-analysis-badge {
  flex: 0 0 auto;
  padding: 7px 10px;
  border: 1px solid rgba(91, 231, 255, .28);
  border-radius: 6px;
  color: var(--cyan);
  background: rgba(5, 35, 54, .68);
  font-size: 11px;
  font-weight: 700;
}

.experiment-dialog-layout {
  display: grid;
  grid-template-columns: minmax(0, 1fr) 260px;
  gap: 18px;
  margin-top: 24px;
}

.experiment-dialog-main,
.experiment-dialog-controls {
  min-width: 0;
  padding: 16px;
  border: 1px solid rgba(133, 171, 233, .22);
  border-radius: 8px;
  background: rgba(2, 13, 31, .68);
}

.experiment-dialog-main > label,
.experiment-dialog-controls label {
  display: grid;
  grid-template-columns: minmax(0, 1fr);
  gap: 7px;
  min-width: 0;
  margin: 0;
  align-items: stretch;
  color: #c9d8ed;
  font-size: 12px;
  font-weight: 700;
}

#experiment-description {
  width: 100%;
  min-height: 142px;
  resize: vertical;
  box-sizing: border-box;
  padding: 13px 14px;
  border: 1px solid rgba(91, 231, 255, .22);
  border-radius: 6px;
  color: var(--text);
  background: rgba(4, 16, 34, .92);
  font: inherit;
  line-height: 1.6;
}

#experiment-description:focus {
  border-color: var(--cyan);
  outline: 2px solid rgba(91, 231, 255, .14);
}

.experiment-example-row {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
  margin-top: 10px;
}

.experiment-example {
  min-height: 30px;
  padding: 5px 9px;
  border-color: rgba(133, 171, 233, .22);
  color: #9fb5d4;
  background: rgba(12, 34, 62, .7);
  font-size: 11px;
}

.experiment-dialog-controls {
  display: grid;
  align-content: start;
  gap: 12px;
}

.experiment-dialog-controls select,
.experiment-dialog-controls button {
  width: 100%;
  min-width: 0;
  max-width: 100%;
}

.experiment-dialog-controls button {
  min-height: 40px;
}

.experiment-plan {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 10px;
  margin-top: 16px;
}

.experiment-plan[hidden] { display: none; }

.experiment-plan-card {
  min-width: 0;
  padding: 12px;
  border: 1px solid rgba(133, 171, 233, .2);
  border-radius: 7px;
  background: rgba(5, 18, 37, .78);
}

.experiment-plan-card span,
.experiment-plan-card small {
  display: block;
  color: var(--muted);
  font-size: 10px;
  line-height: 1.45;
}

.experiment-plan-card strong {
  display: block;
  margin: 5px 0;
  color: var(--cyan);
  font-size: 14px;
}

.experiment-plan-notes {
  grid-column: 1 / -1;
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 10px;
}

.experiment-note-group {
  padding: 11px 12px;
  border-left: 2px solid rgba(91, 231, 255, .5);
  color: #9fb2cf;
  background: rgba(5, 17, 34, .64);
  font-size: 11px;
  line-height: 1.5;
}

.experiment-note-group.warning { border-left-color: #facc15; }
.experiment-note-group.safety { border-left-color: #ff6b7a; }
.experiment-note-group strong { display: block; margin-bottom: 5px; color: #d9e5f5; }
.experiment-note-group ul { margin: 0; padding-left: 17px; }

.experiment-live-result {
  margin-top: 14px;
  padding: 13px 14px;
  border: 1px solid rgba(91, 231, 255, .16);
  border-radius: 7px;
  background: rgba(4, 17, 34, .7);
}

.experiment-live-result strong { color: var(--cyan); }
.experiment-live-result p { margin: 6px 0 0; color: var(--muted); line-height: 1.55; }
.experiment-live-result.is-running { border-color: rgba(91, 231, 255, .42); }

.experiment-endpoint-comparison {
  margin-top: 14px;
  padding-top: 12px;
  border-top: 1px solid rgba(91, 231, 255, .18);
}

.comparison-heading {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 12px;
}

.comparison-heading span {
  color: #7f98bd;
  font-size: 10px;
  text-transform: uppercase;
}

.experiment-comparison-grid {
  display: grid;
  grid-template-columns: repeat(5, minmax(0, 1fr));
  gap: 8px;
  margin-top: 10px;
}

.experiment-comparison-grid article {
  display: grid;
  grid-template-columns: 1fr auto;
  gap: 4px 8px;
  min-width: 0;
  padding: 9px;
  border: 1px solid rgba(133, 171, 233, .18);
  border-radius: 6px;
  background: rgba(3, 15, 32, .7);
}

.experiment-comparison-grid article > span { grid-column: 1 / -1; color: #d9e5f5; font-size: 11px; font-weight: 800; }
.experiment-comparison-grid article b { color: #fff; font-size: 14px; }
.experiment-comparison-grid article i { color: #7f98bd; font-size: 9px; font-style: normal; }
.experiment-comparison-grid article strong { grid-column: 1 / -1; margin-top: 3px; font-size: 12px; }
.experiment-comparison-grid .delta-down { color: #5be0a6; }
.experiment-comparison-grid .delta-up { color: #ff7a89; }

.experiment-safety-note {
  margin: 12px 0 0;
  color: #7f98bd;
  font-size: 11px;
  line-height: 1.5;
}

/* Prepared-plan output overrides the earlier placeholder card grid. */
.experiment-plan {
  display: block;
  padding: 16px;
  border: 1px solid rgba(91, 231, 255, .2);
  border-radius: 8px;
  background: rgba(3, 15, 32, .72);
}

.experiment-plan-status,
.experiment-result-header {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 16px;
}

.experiment-plan-status > div { display: grid; gap: 3px; }
.experiment-plan-status span,
.experiment-plan-grid article span {
  color: var(--muted);
  font-size: 10px;
  letter-spacing: .08em;
  text-transform: uppercase;
}
.experiment-plan-status strong { color: var(--text); }

.confidence-badge {
  padding: 5px 8px;
  border: 1px solid rgba(133, 171, 233, .26);
  border-radius: 5px;
  color: #b9c9df;
  background: rgba(13, 38, 68, .72);
  font-size: 10px;
  font-weight: 800;
  text-transform: uppercase;
}
.confidence-high { border-color: rgba(58, 214, 154, .4); color: #84e9bd; }
.confidence-low { border-color: rgba(255, 107, 122, .44); color: #ff9aa6; }

.experiment-plan-grid {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 10px;
  margin-top: 14px;
}
.experiment-plan-grid article {
  min-width: 0;
  padding: 12px;
  border: 1px solid rgba(133, 171, 233, .2);
  border-radius: 7px;
  background: rgba(5, 18, 37, .78);
}
.experiment-plan-grid article strong { display: block; margin-top: 5px; color: var(--cyan); font-size: 14px; }

.experiment-plan-notes {
  display: block;
  margin-top: 10px;
  padding: 11px 12px;
  border-left: 2px solid rgba(91, 231, 255, .5);
  color: #9fb2cf;
  background: rgba(5, 17, 34, .64);
  font-size: 11px;
  line-height: 1.5;
}
.experiment-plan-notes.missing { border-left-color: #facc15; }
.experiment-plan-notes.safety { border-left-color: #ff6b7a; }
.experiment-plan-notes strong { display: block; margin-bottom: 5px; color: #d9e5f5; }
.experiment-plan-notes ul { margin: 0; padding-left: 17px; }

.experiment-evidence-guidance {
  margin-top: 14px;
  padding-top: 14px;
  border-top: 1px solid rgba(133, 171, 233, .16);
}
.experiment-evidence-guidance > div { display: flex; align-items: center; justify-content: space-between; gap: 14px; }
.experiment-evidence-guidance > div span,
.experiment-evidence-guidance > p { color: var(--muted); font-size: 11px; }
.experiment-evidence-guidance ol { display: grid; gap: 8px; margin: 12px 0; padding-left: 22px; }
.experiment-evidence-guidance li { color: #b7c9e2; }
.experiment-evidence-guidance a { color: #e9f5ff; font-weight: 750; }
.experiment-evidence-guidance small { display: block; margin-top: 3px; color: #78cfea; }
.experiment-evidence-guidance li p { margin: 4px 0 0; color: var(--muted); font-size: 11px; }

.experiment-training-summary {
  margin-top: 14px;
  padding: 14px;
  border: 1px solid rgba(91, 231, 255, .2);
  border-radius: 8px;
  background: rgba(7, 24, 45, .78);
}

.experiment-training-header,
.experiment-training-header > div {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 12px;
}

.experiment-training-header > div { align-items: flex-start; flex-direction: column; gap: 3px; }
.experiment-training-header span { color: var(--muted); font-size: 10px; letter-spacing: .1em; text-transform: uppercase; }
.experiment-training-header strong { color: var(--text); font-size: 14px; }
.experiment-training-header b { color: #f6c85f; font-size: 10px; text-transform: uppercase; }

.experiment-training-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 10px;
  margin-top: 12px;
}

.experiment-training-grid article {
  min-width: 0;
  padding: 12px;
  border: 1px solid rgba(133, 171, 233, .18);
  border-radius: 7px;
  background: rgba(3, 14, 30, .64);
}

.experiment-training-grid h4 { margin: 0 0 8px; font-size: 12px; }
.experiment-training-grid ul,
.experiment-transfer-limits ul { display: grid; gap: 7px; margin: 0; padding-left: 18px; }
.experiment-training-grid li,
.experiment-transfer-limits li { color: #b4c5dc; font-size: 11px; line-height: 1.45; }
.experiment-training-grid li > small { display: block; margin-top: 2px; color: #6fcfe8; }
.experiment-training-grid .effect-decrease { color: #84e9bd; }
.experiment-training-grid .effect-increase { color: #f6c85f; }

.experiment-transfer-limits { margin-top: 10px; border-top: 1px solid rgba(133, 171, 233, .16); padding-top: 10px; }
.experiment-transfer-limits summary { color: var(--cyan); cursor: pointer; font-size: 11px; font-weight: 800; }
.experiment-transfer-limits ul { margin-top: 9px; }
.experiment-transfer-limits p { margin: 9px 0 0; color: var(--muted); font-size: 10px; }
.experiment-result-header span { color: #7f98bd; font: 700 10px/1.2 ui-monospace, SFMono-Regular, Menlo, monospace; }
.experiment-live-result .result-boundary { color: #d4a1aa; font-size: 11px; }

.advanced-research-tools {
  margin: 26px 0;
  border: 1px solid rgba(133, 171, 233, .26);
  border-radius: var(--radius);
  background: rgba(7, 17, 31, .9);
}

.advanced-research-tools > summary {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 24px;
  padding: 22px 26px;
  cursor: pointer;
  list-style: none;
}

.advanced-research-tools > summary::-webkit-details-marker { display: none; }
.advanced-research-tools > summary span:first-child { display: grid; gap: 4px; }
.advanced-research-tools > summary strong { color: var(--text); font-size: 19px; }
.advanced-research-tools > summary em { color: var(--muted); font-size: 12px; font-style: normal; }

.advanced-tools-action {
  flex: 0 0 auto;
  color: var(--cyan);
  font-size: 12px;
  font-weight: 700;
}

.advanced-tools-action::before { content: "+ "; }
.advanced-research-tools[open] .advanced-tools-action::before { content: "- "; }
.advanced-research-tools[open] .advanced-tools-action { font-size: 0; }
.advanced-research-tools[open] .advanced-tools-action::after { content: "Collapse tools"; font-size: 12px; }

.advanced-research-content {
  padding: 0 16px 16px;
  border-top: 1px solid rgba(133, 171, 233, .16);
}

.advanced-research-tools:not([open]) > .advanced-research-content { display: none; }

@media (max-width: 820px) {
  .experiment-workspace-heading { flex-direction: column; }
  .experiment-dialog-layout { grid-template-columns: 1fr; }
  .experiment-training-grid { grid-template-columns: 1fr; }
  .experiment-plan { grid-template-columns: repeat(2, minmax(0, 1fr)); }
  .experiment-plan-notes { grid-template-columns: 1fr; }
}

@media (max-width: 560px) {
  .experiment-plan { grid-template-columns: 1fr; }
  .experiment-plan-notes { grid-column: 1; }
  .advanced-research-tools > summary { align-items: flex-start; flex-direction: column; }
}

.maturity-roadmap-section {
  background:
    radial-gradient(circle at 16% 18%, rgba(91, 231, 255, .12), transparent 30%),
    radial-gradient(circle at 86% 12%, rgba(154, 103, 255, .14), transparent 28%),
    rgba(13, 26, 46, .92);
}

.literature-intelligence-section {
  background:
    linear-gradient(120deg, rgba(55, 163, 255, .08), transparent 46%),
    rgba(9, 22, 40, .96);
}

.literature-section-header {
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: 24px;
}

.literature-section-header .section-heading p:last-child {
  max-width: 760px;
  color: var(--muted);
  line-height: 1.6;
}

.literature-refresh {
  flex: 0 0 42px;
  width: 42px;
  height: 42px;
  font-size: 22px;
}

.literature-refresh.is-loading {
  opacity: .55;
}

.applied-literature-catalog {
  margin-top: 24px;
  padding: 20px;
  border: 1px solid rgba(91, 231, 255, .2);
  border-radius: 8px;
  background: rgba(3, 15, 32, .72);
}
.literature-catalog-heading { display: grid; grid-template-columns: minmax(0, 1fr) 220px; gap: 24px; align-items: start; }
.literature-catalog-heading h3 { margin: 0 0 8px; font-size: 21px; }
.literature-catalog-heading p:not(.eyebrow) { max-width: 820px; margin: 0; color: var(--muted); line-height: 1.55; }
.literature-catalog-heading label { display: grid; gap: 6px; color: #a9bdd9; font-size: 11px; font-weight: 700; }
.training-readiness-summary { margin-top: 18px; padding: 14px; border: 1px solid rgba(91, 231, 255, .22); border-radius: 6px; background: rgba(7, 29, 54, .62); }
.training-readiness-heading { display: flex; align-items: baseline; justify-content: space-between; gap: 16px; }
.training-readiness-heading span { color: #89a5c9; font-size: 10px; font-weight: 800; letter-spacing: .08em; text-transform: uppercase; }
.training-readiness-heading strong { color: #f6d86b; font-size: 13px; }
.training-readiness-metrics { display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); margin-top: 12px; border-block: 1px solid rgba(133, 171, 233, .16); }
.training-readiness-metrics span { display: grid; gap: 2px; min-width: 0; padding: 10px 12px; border-right: 1px solid rgba(133, 171, 233, .14); }
.training-readiness-metrics span:last-child { border-right: 0; }
.training-readiness-metrics b { color: var(--cyan); font-size: 20px; }
.training-readiness-metrics small { color: #9fb2cf; line-height: 1.35; }
.training-readiness-summary > p { margin: 10px 0 0; color: #aebed5; font-size: 11px; line-height: 1.55; }
.literature-catalog-list { display: grid; margin-top: 18px; border-top: 1px solid rgba(133, 171, 233, .18); }
.literature-catalog-card { display: grid; grid-template-columns: 72px minmax(0, 1fr); gap: 16px; padding: 16px 4px; border-bottom: 1px solid rgba(133, 171, 233, .14); }
.literature-rank { display: grid; align-content: start; text-align: center; }
.literature-rank span { color: #617a9e; font-size: 10px; }
.literature-rank strong { color: var(--cyan); font-size: 20px; }
.literature-rank small { color: #617a9e; font-size: 9px; }
.literature-card-meta,
.literature-provenance { display: flex; flex-wrap: wrap; gap: 6px; }
.literature-card-meta span,
.literature-provenance span { padding: 3px 6px; border: 1px solid rgba(133, 171, 233, .16); border-radius: 4px; color: #83a1c7; background: rgba(13, 38, 68, .55); font-size: 9px; text-transform: uppercase; }
.literature-card-meta .priority-author { border-color: rgba(154, 103, 255, .45); color: #c8adff; }
.literature-card-copy h4 { margin: 7px 0 5px; font-size: 16px; line-height: 1.35; }
.literature-card-copy h4 a { color: #eff7ff; }
.literature-card-copy > p { margin: 4px 0; color: var(--muted); font-size: 11px; line-height: 1.5; }
.literature-card-copy .literature-model-use { color: #b7c9e2; }
.literature-provenance { margin-top: 9px; }
.candidate-model-boundary { margin-top: 16px; padding: 12px 14px; border-left: 3px solid #facc15; background: rgba(67, 52, 5, .18); }
.candidate-model-boundary strong { color: #f6d86b; }
.candidate-model-boundary p { margin: 5px 0 0; color: #aebed5; font-size: 11px; line-height: 1.55; }

.literature-status-grid {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  margin-top: 24px;
  border-block: 1px solid rgba(133, 171, 233, .22);
}

.literature-status-item {
  min-height: 112px;
  padding: 20px;
  border-right: 1px solid rgba(133, 171, 233, .18);
}

.literature-status-item:last-child {
  border-right: 0;
}

.literature-status-item > span,
.literature-status-item > em {
  display: block;
  color: var(--muted);
  font-size: 12px;
  font-style: normal;
  line-height: 1.4;
}

.literature-status-item > span {
  margin-bottom: 12px;
  font-weight: 800;
  letter-spacing: .08em;
  text-transform: uppercase;
}

.literature-status-item > strong {
  display: flex;
  align-items: center;
  gap: 9px;
  min-height: 24px;
  color: #fff;
  font-size: 18px;
}

.literature-status-item > strong.blocked {
  color: #ff7b83;
}

.service-status-dot {
  display: inline-block;
  flex: 0 0 9px;
  width: 9px;
  height: 9px;
  border-radius: 50%;
  background: var(--warn);
}

.service-status-dot.online { background: var(--green); }
.service-status-dot.offline { background: var(--warn); }
.service-status-dot.checking { background: var(--cyan); }

.literature-budget-track {
  width: 100%;
  height: 5px;
  margin-top: 14px;
  overflow: hidden;
  border-radius: 3px;
  background: rgba(133, 171, 233, .16);
}

.literature-budget-track i {
  display: block;
  width: 0;
  height: 100%;
  background: linear-gradient(90deg, var(--cyan), var(--green));
  transition: width .25s ease;
}

.literature-budget-track i.blocked {
  background: #ff5964;
}

.literature-service-message {
  margin: 18px 0 0;
  color: var(--muted);
  font-size: 13px;
  line-height: 1.55;
}

.literature-audit-summary {
  display: flex;
  flex-wrap: wrap;
  gap: 8px 16px;
  margin-top: 12px;
  color: var(--muted);
  font-size: 12px;
}

.literature-audit-summary span {
  white-space: nowrap;
}

.literature-audit-summary strong {
  color: #dff8ff;
  font-size: 15px;
  font-variant-numeric: tabular-nums;
}

.model-audit-summary {
  display: flex;
  flex-wrap: wrap;
  gap: 8px 16px;
  margin-top: 14px;
  color: var(--muted);
  font-size: 12px;
}

.model-audit-summary strong { color: #dff8ff; }
.model-audit-status { text-transform: capitalize; }
.model-audit-status--review_required { color: #ffb4a8; }

.literature-audit-summary.has-review-items strong {
  color: #ffb4a8;
}

.pubmed-search-form {
  display: grid;
  gap: 9px;
  margin-top: 20px;
  max-width: 920px;
}

.pubmed-search-form > label {
  color: #dbeafe;
  font-size: 12px;
  font-weight: 800;
  letter-spacing: .08em;
  text-transform: uppercase;
}

.pubmed-search-row {
  display: grid;
  grid-template-columns: minmax(0, 1fr) 142px 132px auto;
  gap: 10px;
}

.pubmed-search-row input,
.pubmed-search-row select {
  min-width: 0;
  min-height: 42px;
  padding: 0 12px;
  border: 1px solid rgba(133, 171, 233, .28);
  border-radius: 7px;
  background: rgba(4, 14, 29, .8);
  color: #f8fbff;
}

.pubmed-search-row input::placeholder {
  color: #6f86a8;
}

.pubmed-search-row .primary-button {
  min-height: 42px;
  padding: 0 16px;
  border: 0;
  border-radius: 7px;
  background: var(--cyan);
  color: #061226;
  cursor: pointer;
  font-weight: 800;
}

.pubmed-search-row .primary-button:disabled {
  cursor: wait;
  opacity: .55;
}

.pubmed-abstract-option {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  margin-top: 12px;
  color: #9db2d8;
  font-size: 13px;
}

.pubmed-abstract-option input {
  accent-color: #4ab8ff;
}

.chart-toolbar-actions {
  display: inline-flex;
  align-items: center;
  gap: 8px;
}

.drug-comparison-toolbar {
  display: flex;
  align-items: end;
  gap: 12px;
  margin: 18px 0;
}

.drug-comparison-toolbar label {
  display: grid;
  gap: 6px;
  color: var(--muted);
  font-size: 12px;
  font-weight: 800;
  letter-spacing: .04em;
  text-transform: uppercase;
}

.drug-comparison-toolbar select,
.drug-comparison-toolbar button {
  min-height: 40px;
  border: 1px solid rgba(133, 171, 233, .28);
  border-radius: 7px;
  padding: 0 12px;
  background: rgba(4, 14, 29, .8);
  color: var(--text);
}

.drug-comparison-toolbar button {
  background: var(--blue);
  color: #061226;
  cursor: pointer;
  font-weight: 800;
}

.drug-comparison-grid {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 12px;
}

.drug-comparison-card {
  padding: 16px;
  border: 1px solid rgba(133, 171, 233, .2);
  border-radius: var(--radius);
  background: rgba(7, 17, 31, .62);
}

.comparison-metric {
  display: grid;
  grid-template-columns: 1fr auto;
  gap: 4px 8px;
  margin-top: 12px;
  color: var(--muted);
  font-size: 11px;
}

.comparison-metric b { color: var(--text); }
.comparison-metric i {
  grid-column: 1 / -1;
  display: block;
  height: 4px;
  border-radius: 3px;
  background: linear-gradient(90deg, var(--cyan) var(--score-width), rgba(133, 171, 233, .16) var(--score-width));
}

.drug-comparison-card small {
  display: block;
  margin-top: 14px;
  color: #7890b3;
  font-size: 10px;
}

.validation-dataset-form {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 12px;
  margin: 18px 0;
}

.validation-dataset-form label {
  display: grid;
  gap: 6px;
  color: var(--muted);
  font-size: 12px;
  font-weight: 800;
}

.validation-dataset-form input,
.validation-dataset-form select {
  min-height: 38px;
  border: 1px solid rgba(133, 171, 233, .28);
  border-radius: 7px;
  padding: 0 10px;
  background: rgba(4, 14, 29, .8);
  color: var(--text);
}

.validation-dataset-form button,
.validation-result-header button {
  min-height: 38px;
  border: 0;
  border-radius: 7px;
  padding: 0 14px;
  background: var(--blue);
  color: #061226;
  cursor: pointer;
  font-weight: 800;
}

.validation-confirmation {
  display: flex !important;
  align-items: center;
  grid-column: span 1;
}

.validation-confirmation input { min-height: auto; }

.validation-file-input {
  align-content: center;
  color: #9db2d8 !important;
}

.validation-template-link {
  align-self: center;
  color: var(--cyan);
  font-size: 12px;
  font-weight: 800;
  text-decoration: none;
}

.validation-template-link:hover { text-decoration: underline; }

.validation-result-header,
.validation-result-row {
  display: grid;
  grid-template-columns: 1fr auto auto;
  gap: 12px;
  align-items: center;
  padding: 10px 0;
  border-bottom: 1px solid rgba(133, 171, 233, .14);
}

.validation-result-header { grid-template-columns: 1fr auto; }
.validation-result-row span { color: var(--muted); }
.validation-result-row b { color: var(--text); font-size: 12px; }
.validation-dataset-results small { display: block; margin-top: 10px; color: #7890b3; }

.validation-candidates {
  margin-top: 14px;
  padding-top: 12px;
  border-top: 1px solid rgba(133, 171, 233, .14);
}

.validation-candidates strong { color: #dff8ff; font-size: 12px; }
.validation-candidates p { margin: 8px 0 0; color: var(--muted); font-size: 12px; line-height: 1.5; }

.pubmed-search-status {
  min-height: 18px;
  margin: 0;
  color: var(--muted);
  font-size: 12px;
}

.local-literature-details {
  margin-top: 18px;
  border-top: 1px solid rgba(133, 171, 233, .18);
  padding-top: 14px;
}

.local-literature-details summary {
  cursor: pointer;
  color: #dbeafe;
  font-size: 13px;
  font-weight: 800;
}

.local-literature-records {
  display: grid;
  gap: 8px;
  margin-top: 12px;
}

.local-literature-record {
  display: grid;
  gap: 4px;
  padding: 10px 12px;
  border: 1px solid rgba(133, 171, 233, .16);
  border-radius: 8px;
  background: rgba(255, 255, 255, .035);
}

.local-literature-record a {
  color: var(--cyan);
  font-size: 13px;
  font-weight: 700;
  text-decoration: none;
}

.local-literature-record a:hover,
.local-literature-record a:focus-visible {
  text-decoration: underline;
}

.local-literature-record span {
  color: var(--muted);
  font-size: 11px;
}

.annotation-function {
  margin: 4px 0 0;
  color: #c9d8f1;
  font-size: 11px;
  line-height: 1.5;
}

.local-record-snippets {
  margin-top: 6px;
  color: #c9d8f1;
  font-size: 11px;
}

.local-record-snippets summary {
  cursor: pointer;
  color: var(--cyan);
  font-weight: 700;
}

.local-record-snippets ul {
  display: grid;
  gap: 6px;
  margin: 8px 0 0 16px;
  padding: 0;
}

.feedback-details {
  margin-top: 18px;
  border-top: 1px solid rgba(133, 171, 233, .18);
  padding-top: 14px;
}

.feedback-details summary {
  cursor: pointer;
  color: #dbeafe;
  font-size: 13px;
  font-weight: 800;
}

.feedback-note {
  max-width: 760px;
  margin: 12px 0;
  color: var(--muted);
  font-size: 12px;
  line-height: 1.5;
}

.research-feedback-form {
  display: grid;
  gap: 12px;
  max-width: 980px;
}

.feedback-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 12px;
}

.feedback-grid label {
  display: grid;
  gap: 6px;
  color: var(--muted);
  font-size: 12px;
}

.feedback-grid input,
.feedback-grid select,
.feedback-grid textarea {
  width: 100%;
  box-sizing: border-box;
  padding: 9px 10px;
  border: 1px solid rgba(133, 171, 233, .25);
  border-radius: 7px;
  background: rgba(4, 14, 29, .8);
  color: #f8fbff;
  font: inherit;
}

.feedback-grid textarea {
  resize: vertical;
}

.feedback-confirmation {
  display: flex;
  align-items: flex-start;
  gap: 8px;
  color: #dbeafe;
  font-size: 12px;
  line-height: 1.5;
}

.maturity-layout {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 14px;
  margin-bottom: 22px;
}

.maturity-card,
.roadmap-step,
.data-upgrade-panel {
  border: 1px solid rgba(133, 171, 233, .20);
  border-radius: 10px;
  background: rgba(255, 255, 255, .045);
}

.maturity-card {
  padding: 18px;
}

.maturity-card.active {
  border-color: rgba(91, 231, 255, .45);
  background: linear-gradient(135deg, rgba(55, 163, 255, .18), rgba(154, 103, 255, .09));
  box-shadow: 0 18px 38px rgba(55, 163, 255, .10);
}

.maturity-card span,
.roadmap-step span {
  display: block;
  margin-bottom: 8px;
  color: var(--cyan);
  font-size: 12px;
  font-weight: 800;
  letter-spacing: .12em;
  text-transform: uppercase;
}

.maturity-card strong,
.roadmap-step strong,
.data-upgrade-panel h3 {
  display: block;
  color: #fff;
}

.maturity-card strong {
  font-size: 20px;
  line-height: 1.25;
}

.maturity-card p,
.roadmap-step p {
  margin: 10px 0 0;
  color: var(--muted);
  line-height: 1.55;
}

.roadmap-grid {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 14px;
}

.roadmap-step {
  position: relative;
  min-height: 170px;
  padding: 18px;
  overflow: hidden;
}

.roadmap-step::after {
  content: "";
  position: absolute;
  inset: auto 14px 14px auto;
  width: 42px;
  height: 3px;
  border-radius: 999px;
  background: rgba(133, 171, 233, .24);
}

.roadmap-step.done::after {
  background: var(--green);
}

.roadmap-step.next {
  border-color: rgba(246, 200, 95, .50);
}

.roadmap-step.next::after {
  background: var(--warn);
}

.roadmap-step strong {
  font-size: 17px;
  line-height: 1.3;
}

.data-upgrade-panel {
  margin-top: 16px;
  padding: 18px;
}

.data-upgrade-panel h3 {
  margin: 0 0 12px;
  font-size: 18px;
}

.data-upgrade-panel div {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
}

.data-upgrade-panel span {
  display: inline-flex;
  min-height: 32px;
  align-items: center;
  border: 1px solid rgba(91, 231, 255, .16);
  border-radius: 999px;
  padding: 6px 11px;
  color: var(--muted);
  background: rgba(3, 12, 28, .36);
  font-size: 12px;
}

.biomarker-panel {
  display: block;
  margin-top: 16px;
  border: 1px solid rgba(91, 231, 255, .22);
  border-radius: 10px;
  background: rgba(3, 12, 28, .30);
}

.biomarker-panel > summary {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 18px;
  padding: 18px;
  cursor: pointer;
  list-style: none;
}

.biomarker-panel > summary::-webkit-details-marker {
  display: none;
}

.biomarker-panel > summary::after {
  content: "+";
  display: grid;
  place-items: center;
  flex: 0 0 34px;
  height: 34px;
  border: 1px solid rgba(91, 231, 255, .30);
  border-radius: 8px;
  color: var(--cyan);
  font-size: 22px;
}

.biomarker-panel[open] > summary::after {
  content: "-";
}

.biomarker-panel > summary strong {
  display: block;
  margin: 5px 0;
  color: #fff;
  font-size: 22px;
}

.biomarker-panel > summary em {
  display: block;
  color: var(--muted);
  font-style: normal;
  line-height: 1.5;
}

.biomarker-layout {
  display: grid;
  grid-template-columns: minmax(330px, .52fr) minmax(0, .48fr);
  gap: 16px;
  border-top: 1px solid rgba(133, 171, 233, .16);
  padding: 18px;
}

.biomarker-form {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 10px;
}

.biomarker-form label {
  display: grid;
  grid-template-columns: 82px minmax(0, 1fr) 58px;
  gap: 8px;
  align-items: center;
  min-height: 42px;
  border: 1px solid rgba(91, 231, 255, .14);
  border-radius: 8px;
  padding: 8px;
  background: rgba(255,255,255,.035);
}

.biomarker-form label span {
  color: var(--muted);
  font-size: 11px;
  text-align: right;
}

.biomarker-actions {
  grid-column: 1 / -1;
  display: flex;
  flex-wrap: wrap;
  gap: 10px;
}

.biomarker-actions button {
  min-height: 40px;
  border: 1px solid rgba(91, 231, 255, .32);
  border-radius: 8px;
  padding: 0 14px;
  color: #fff;
  background: rgba(55, 163, 255, .16);
  cursor: pointer;
}

.biomarker-actions button:last-child {
  background: linear-gradient(90deg, var(--blue), var(--violet));
}

.biomarker-results {
  display: grid;
  align-content: start;
  gap: 12px;
}

.biomarker-estimate-cards {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 10px;
}

.biomarker-estimate-card {
  border: 1px solid rgba(91, 231, 255, .16);
  border-radius: 8px;
  padding: 12px;
  background: rgba(255,255,255,.04);
}

.biomarker-estimate-card span {
  display: block;
  color: var(--muted);
  font-size: 12px;
}

.biomarker-estimate-card strong {
  display: block;
  margin: 6px 0 8px;
  color: #fff;
  font-size: 24px;
}

.biomarker-estimate-card i {
  display: block;
  width: var(--score-width);
  height: 6px;
  border-radius: 999px;
  background: linear-gradient(90deg, var(--blue), var(--cyan));
}

.biomarker-interpretation,
.biomarker-disclaimer {
  margin: 0;
  color: var(--muted);
  line-height: 1.55;
}

.biomarker-disclaimer {
  color: #facc15;
  font-size: 12px;
}

.section-heading {
  max-width: 900px;
  margin-bottom: 26px;
}

.section-heading h2 { margin-bottom: 0; }

.pathway-canvas {
  display: grid;
  grid-template-columns: 1fr 220px 1fr;
  gap: 24px;
  align-items: center;
  min-height: 470px;
}

.pathway-column {
  display: grid;
  gap: 18px;
}

.pathway-card {
  min-height: 122px;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  padding: 20px;
  background: linear-gradient(135deg, rgba(255,255,255,.08), rgba(255,255,255,.025));
}

.pathway-card span,
.publication-card span {
  display: block;
  margin-bottom: 10px;
  color: var(--cyan);
  font-size: 12px;
  font-weight: 800;
  letter-spacing: .12em;
  text-transform: uppercase;
}

.pathway-card strong {
  display: block;
  font-size: 18px;
  line-height: 1.45;
}

.pathway-spine {
  display: grid;
  place-items: center;
  gap: 14px;
}

.spine-node {
  width: 190px;
  min-height: 70px;
  display: grid;
  place-items: center;
  border-radius: 999px;
  border: 1px solid rgba(91, 231, 255, .65);
  background: radial-gradient(circle at 35% 25%, rgba(91,231,255,.30), rgba(55,163,255,.08));
  color: white;
  font-weight: 900;
  text-align: center;
  cursor: pointer;
}

.spine-arrow {
  width: 2px;
  height: 54px;
  background: linear-gradient(var(--cyan), var(--violet));
}

.two-column {
  display: grid;
  grid-template-columns: minmax(0, 1.4fr) minmax(330px, .6fr);
  gap: 26px;
  align-items: start;
}

.compact { align-items: stretch; }

.graph-toolbar {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
  margin-bottom: 14px;
}

.filter-button,
.list-panel button {
  border: 1px solid var(--line);
  color: var(--text);
  background: rgba(255,255,255,.05);
  border-radius: 6px;
  cursor: pointer;
}

.filter-button {
  min-height: 38px;
  padding: 0 13px;
}

.filter-button.active,
.filter-button:hover,
.list-panel button:hover {
  border-color: rgba(91, 231, 255, .72);
  background: rgba(55, 163, 255, .18);
}

.graph {
  min-height: 620px;
  overflow: visible;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  padding: 18px;
  background:
    radial-gradient(circle at 50% 45%, rgba(91, 231, 255, .17), transparent 28%),
    linear-gradient(135deg, rgba(255,255,255,.04), rgba(255,255,255,.015));
}

.graph-group {
  margin-bottom: 18px;
  padding: 16px;
  border: 1px solid rgba(91, 231, 255, .16);
  border-radius: var(--radius);
  background: rgba(4, 12, 24, .36);
}

.graph-group:last-child {
  margin-bottom: 0;
}

.graph-group h3 {
  margin: 0 0 12px;
  color: var(--cyan);
  font-size: 13px;
  letter-spacing: .12em;
  text-transform: uppercase;
}

.graph-node-grid {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(132px, 1fr));
  gap: 10px;
}

.graph-node {
  min-height: 72px;
  width: 100%;
  padding: 12px;
  border: 1px solid rgba(91, 231, 255, .36);
  border-radius: 8px;
  color: white;
  background: rgba(13, 26, 46, .94);
  cursor: pointer;
  text-align: left;
  white-space: normal;
  overflow-wrap: anywhere;
}

.graph-node strong {
  display: block;
  margin-bottom: 6px;
  font-size: 15px;
  line-height: 1.15;
}

.graph-node span {
  display: block;
  color: var(--muted);
  font-size: 11px;
  line-height: 1.2;
  text-transform: capitalize;
}

.graph-node.active {
  border-color: white;
  background: linear-gradient(90deg, var(--blue), var(--violet));
  box-shadow: 0 0 0 5px rgba(55, 163, 255, .15);
}

.graph-node.active span {
  color: rgba(255,255,255,.82);
}

.graph-node.disease { background: rgba(126, 72, 255, .55); }
.graph-node.drug { background: rgba(85, 224, 166, .42); }
.graph-node.regulator { background: rgba(246, 200, 95, .35); }
.graph-node.biomarker { background: rgba(91, 231, 255, .24); }

.details-panel {
  min-height: 420px;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  padding: 24px;
  background: rgba(255,255,255,.055);
}

.details-panel h3 {
  margin-bottom: 12px;
  font-size: 26px;
}

.muted {
  color: var(--muted);
  line-height: 1.65;
}

.tag-block {
  margin: 18px 0;
}

.tag-block strong,
.relationship-list strong,
.model-note strong {
  display: block;
  margin-bottom: 8px;
  color: white;
  font-size: 13px;
  letter-spacing: .08em;
  text-transform: uppercase;
}

.tag-block div {
  display: flex;
  flex-wrap: wrap;
  gap: 7px;
}

.tag-block span {
  display: inline-flex;
  min-height: 28px;
  align-items: center;
  padding: 0 10px;
  border: 1px solid var(--line);
  border-radius: 999px;
  color: var(--text);
  background: rgba(255,255,255,.05);
  font-size: 12px;
}

.relationship-list p,
.model-note p {
  margin: 8px 0;
  color: var(--muted);
  line-height: 1.55;
}

.relationship-list span { color: var(--cyan); }

.simulation-grid {
  display: grid;
  grid-template-columns: minmax(340px, .48fr) minmax(0, .52fr);
  gap: 24px;
}

.control-panel {
  display: grid;
  gap: 14px;
}

fieldset {
  margin: 0;
  padding: 18px;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  background: rgba(255,255,255,.04);
}

legend {
  padding: 0 8px;
  color: var(--cyan);
  font-size: 12px;
  font-weight: 800;
  letter-spacing: .12em;
  text-transform: uppercase;
}

label {
  display: grid;
  grid-template-columns: minmax(120px, 1fr) minmax(120px, 1fr) 36px;
  gap: 12px;
  align-items: center;
  margin: 12px 0;
  color: var(--muted);
  font-size: 13px;
}

input[type="range"] {
  width: 100%;
  accent-color: var(--blue);
}

input[type="number"] {
  width: 100%;
  height: 36px;
  border: 1px solid var(--line);
  border-radius: 6px;
  color: var(--text);
  background: #081529;
  padding: 0 10px;
}

output {
  color: white;
  font-variant-numeric: tabular-nums;
}

select {
  width: 100%;
  height: 42px;
  border: 1px solid var(--line);
  border-radius: 6px;
  color: var(--text);
  background: #081529;
  padding: 0 12px;
}

.result-cards {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 14px;
}

.result-card {
  min-height: 118px;
  padding: 18px;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  background: rgba(255,255,255,.05);
}

.result-card span {
  color: var(--muted);
  font-size: 13px;
  line-height: 1.3;
}

.result-card strong {
  display: block;
  margin: 9px 0;
  font-size: 34px;
}

.score-bar {
  height: 7px;
  overflow: hidden;
  border-radius: 999px;
  background: rgba(255,255,255,.12);
}

.score-bar i {
  display: block;
  height: 100%;
  border-radius: inherit;
  background: var(--green);
}

.result-card.medium .score-bar i { background: var(--warn); }
.result-card.high .score-bar i { background: var(--red); }

.summary-box {
  margin-top: 16px;
  padding: 22px;
  border: 1px solid rgba(91, 231, 255, .32);
  border-radius: var(--radius);
  background: linear-gradient(135deg, rgba(55,163,255,.15), rgba(154,103,255,.08));
}

.simulation-traceability {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 10px;
  margin-top: 14px;
}

.simulation-traceability span {
  display: grid;
  gap: 4px;
  min-width: 0;
  padding: 11px 12px;
  border: 1px solid var(--line);
  background: rgba(9, 22, 48, 0.55);
}

.simulation-traceability small {
  color: var(--muted);
  font-size: 0.68rem;
  letter-spacing: 0.08em;
  text-transform: uppercase;
}

.simulation-traceability strong {
  overflow-wrap: anywhere;
  color: var(--text);
  font-size: 0.78rem;
  line-height: 1.35;
}

.model-history-panel {
  display: grid;
  grid-template-columns: minmax(0, .8fr) minmax(0, 1.2fr);
  gap: 22px;
  margin-top: 18px;
  padding: 18px;
  border: 1px solid var(--line);
  background: rgba(9, 22, 48, .45);
}

.model-history-panel h3 {
  margin: 0 0 8px;
  color: var(--text);
  font-size: 1rem;
}

.model-history-panel p:not(.eyebrow) {
  margin: 0;
  color: var(--muted);
  font-size: .84rem;
  line-height: 1.55;
}

.model-history-list {
  display: grid;
  gap: 10px;
}

.model-release-card {
  display: grid;
  gap: 6px;
  padding: 12px;
  border: 1px solid rgba(91, 231, 255, .2);
  background: rgba(2, 10, 27, .55);
}

.model-release-card header {
  display: flex;
  justify-content: space-between;
  gap: 10px;
}

.model-release-card header strong { color: var(--text); font-size: .82rem; }
.model-release-card header span { color: var(--cyan); font-size: .72rem; text-transform: uppercase; }
.model-release-card p { color: var(--text) !important; font-size: .78rem !important; }
.model-release-card small { color: var(--muted); font-size: .68rem; }
.model-history-empty { color: var(--muted); font-size: .8rem; }

@media (max-width: 760px) {
  .simulation-traceability {
    grid-template-columns: 1fr;
  }

  .model-history-panel {
    grid-template-columns: 1fr;
  }
}

.summary-box p:last-child {
  margin-bottom: 0;
  color: var(--text);
  font-size: 17px;
  line-height: 1.65;
}

.dynamics-section {
  background:
    radial-gradient(circle at 76% 16%, rgba(91, 231, 255, .10), transparent 28%),
    rgba(13, 26, 46, .94);
}

.advanced-dynamics-details {
  display: block;
}

.advanced-dynamics-details > summary {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 18px;
  min-height: 86px;
  border: 1px solid rgba(91, 231, 255, .22);
  border-radius: var(--radius);
  padding: 20px 22px;
  background: linear-gradient(135deg, rgba(255,255,255,.07), rgba(255,255,255,.025));
  cursor: pointer;
  list-style: none;
}

.advanced-dynamics-details > summary::-webkit-details-marker {
  display: none;
}

.advanced-dynamics-details > summary::after {
  content: "+";
  display: grid;
  place-items: center;
  flex: 0 0 38px;
  height: 38px;
  border: 1px solid rgba(91, 231, 255, .34);
  border-radius: 8px;
  color: var(--cyan);
  font-size: 24px;
  line-height: 1;
}

.advanced-dynamics-details[open] > summary::after {
  content: "-";
}

.advanced-dynamics-details > summary strong {
  display: block;
  margin: 5px 0 6px;
  color: #fff;
  font-size: 24px;
}

.advanced-dynamics-details > summary em {
  display: block;
  max-width: 860px;
  color: var(--muted);
  font-style: normal;
  line-height: 1.55;
}

.advanced-dynamics-details[open] > .dynamics-layout {
  margin-top: 22px;
}

.dynamics-layout {
  display: grid;
  grid-template-columns: minmax(310px, .34fr) minmax(0, .66fr);
  gap: 24px;
  align-items: start;
}

.dynamics-controls {
  max-height: 980px;
  overflow: auto;
  padding-right: 4px;
}

.dynamics-controls label {
  grid-template-columns: minmax(112px, .8fr) minmax(0, 1fr) 36px;
}

.dynamics-controls label:has(select),
.dynamics-controls label:has(input[type="number"]) {
  grid-template-columns: minmax(112px, .8fr) minmax(0, 1fr);
}

.checkbox-row {
  display: flex !important;
  align-items: center;
  gap: 9px;
  min-height: 30px;
  margin: 8px 0;
  color: var(--text);
}

.checkbox-row input {
  width: auto;
}

.button-row {
  display: flex;
  gap: 8px;
  margin-bottom: 10px;
}

.button-row button,
.chart-toolbar button {
  min-height: 34px;
  border: 1px solid var(--line);
  border-radius: 6px;
  color: var(--text);
  background: rgba(255,255,255,.06);
  cursor: pointer;
  padding: 0 12px;
}

.button-row button:hover,
.chart-toolbar button:hover {
  border-color: rgba(91, 231, 255, .72);
}

.group-filter-list {
  display: grid;
  grid-template-columns: 1fr;
  gap: 4px;
}

.dynamics-main {
  min-width: 0;
}

.chart-toolbar {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 14px;
  margin-bottom: 12px;
}

.chart-toolbar h3 {
  margin: 0;
  font-size: 21px;
}

.dynamics-chart {
  min-height: 620px;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  overflow: hidden;
  background: #0b1628;
}

.plotly-fallback {
  min-height: 620px;
  display: grid;
  place-items: center;
  color: var(--muted);
  padding: 28px;
  text-align: center;
}

.time-inspector-control {
  margin: 14px 0;
  padding: 12px 14px;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  background: rgba(255,255,255,.04);
}

.time-inspector-control label {
  grid-template-columns: 180px minmax(0, 1fr) 54px;
  margin: 0;
}

.dynamics-bottom {
  display: grid;
  grid-template-columns: minmax(0, .9fr) minmax(0, 1fr);
  gap: 14px;
}

.event-panel,
.inspector-panel,
.interpretation-panel {
  border: 1px solid var(--line);
  border-radius: var(--radius);
  background: rgba(255,255,255,.05);
  padding: 18px;
}

.interpretation-panel {
  grid-column: 1 / -1;
}

.interpretation-panel p:last-child {
  color: var(--muted);
  line-height: 1.65;
}

.timeline-event {
  position: relative;
  padding: 0 0 16px 18px;
  border-left: 1px solid rgba(91, 231, 255, .34);
}

.timeline-event::before {
  content: "";
  position: absolute;
  left: -5px;
  top: 3px;
  width: 9px;
  height: 9px;
  border-radius: 50%;
  background: var(--cyan);
}

.timeline-event strong {
  display: block;
  color: var(--cyan);
  font-size: 12px;
}

.timeline-event span {
  display: block;
  margin: 4px 0;
  color: white;
  font-weight: 800;
}

.timeline-event p {
  margin-bottom: 0;
  color: var(--muted);
  font-size: 13px;
  line-height: 1.45;
}

.inspector-panel h3 {
  margin: 0 0 12px;
}

.inspector-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 8px;
}

.inspector-grid span {
  display: flex;
  justify-content: space-between;
  gap: 10px;
  padding: 8px 10px;
  border: 1px solid rgba(133,171,233,.18);
  border-radius: 6px;
  background: rgba(0,0,0,.12);
  color: var(--text);
  font-variant-numeric: tabular-nums;
}

.inspector-grid strong {
  color: var(--muted);
  font-weight: 700;
}

.list-panel {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 12px;
}

.list-panel button {
  min-height: 82px;
  padding: 15px;
  text-align: left;
  font-weight: 800;
}

.list-panel span {
  display: block;
  margin-top: 8px;
  color: var(--muted);
  font-size: 12px;
  font-weight: 500;
}

.evidence-section,
.evidence-section .section-heading {
  color: var(--ink);
}

.evidence-section {
  background: var(--panel-3);
  border-color: #dce7fa;
}

.evidence-section .eyebrow { color: #126cff; }

.publication-grid {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 14px;
}

.publication-card {
  min-height: 230px;
  padding: 20px;
  border: 1px solid #dce7fa;
  border-radius: var(--radius);
  background: white;
  box-shadow: 0 18px 48px rgba(24, 55, 112, .08);
}

.publication-card h3 {
  color: var(--ink);
  font-size: 18px;
}

.publication-card p {
  color: #4b5d82;
  line-height: 1.55;
}

.publication-card .tag-block strong { color: var(--ink); }
.publication-card .tag-block span { color: #17305d; background: #f3f7ff; border-color: #dce7fa; }

@media (max-width: 980px) {
  .app-shell { width: min(100% - 24px, 720px); }
  .hero, .two-column, .simulation-grid, .pathway-canvas, .dynamics-layout, .dynamics-bottom, .maturity-layout, .roadmap-grid, .biomarker-layout, .biomarker-form, .biomarker-estimate-cards, .literature-status-grid, .drug-comparison-grid, .validation-dataset-form { grid-template-columns: 1fr; }
  .hero { min-height: auto; padding: 60px 0 24px; }
  .hero::after { inset: 48% 0 0 0; }
  .pathway-spine { grid-template-columns: 1fr; }
  .section { padding: 24px; }
  .result-cards, .list-panel, .publication-grid { grid-template-columns: 1fr; }
  .amd-dashboard-grid,
  .amd-output-grid,
  .amd-chip-grid,
  .amd-calibration-priors { grid-template-columns: 1fr; }
  .amd-dashboard-header { align-items: flex-start; flex-direction: column; }
  label { grid-template-columns: 1fr; gap: 6px; }
  .dynamics-controls label,
  .dynamics-controls label:has(select),
  .dynamics-controls label:has(input[type="number"]),
  .time-inspector-control label { grid-template-columns: 1fr; }
  .literature-section-header { align-items: center; }
  .pubmed-search-row { grid-template-columns: 1fr; }
  .drug-comparison-toolbar { align-items: stretch; flex-direction: column; }
  .feedback-grid { grid-template-columns: 1fr; }
  .microstructure-panels { grid-template-columns: 1fr; }
  .microstructure-header, .microstructure-header-actions { flex-direction: column; align-items: flex-start; }
  .literature-status-item { border-right: 0; border-bottom: 1px solid rgba(133, 171, 233, .18); }
  .literature-status-item:last-child { border-bottom: 0; }
  .literature-catalog-heading { grid-template-columns: 1fr; }
  .training-readiness-heading { align-items: flex-start; flex-direction: column; }
  .training-readiness-metrics { grid-template-columns: repeat(2, minmax(0, 1fr)); }
  .training-readiness-metrics span:nth-child(2) { border-right: 0; }
  .training-readiness-metrics span:nth-child(-n+2) { border-bottom: 1px solid rgba(133, 171, 233, .14); }
  .hero > * { min-width: 0; }
  .hero-copy,
  .hero-panel,
  .hero-dynamics-preview { width: 100%; max-width: 100%; }
  .hero-dynamics-preview { padding: 12px; overflow: hidden; }
  .hero-toolbar-header { align-items: stretch; flex-direction: column; }
  .hero-top-right-controls { justify-content: flex-start; flex-wrap: wrap; margin-left: 0; white-space: normal; }
  .hero-playback-controls > label,
  .hero-highlight-control { white-space: normal; }
  .hero-inhibitor-set { width: 100%; flex-wrap: wrap; }
  .hero-playback-controls .hero-intervention-time-control { min-width: 0; }
  .hero-dynamics-chart,
  .organ-impact-twin,
  .organ-body-panel,
  .organ-impact-panel { width: 100%; min-width: 0; max-width: 100%; }
  .experiment-comparison-grid { grid-template-columns: 1fr; }
}

@media (max-width: 820px) {
  .experiment-plan-grid { grid-template-columns: repeat(2, minmax(0, 1fr)); }
}

@media (max-width: 560px) {
  .human-twin {
    min-height: 650px;
    place-items: start center;
    padding-top: 158px;
  }
  .heartbeat-monitor {
    top: -150px;
    left: 50%;
    width: 200px;
    min-width: 0;
    transform: translateX(-50%);
  }
  .experiment-plan-grid { grid-template-columns: 1fr; }
  .experiment-plan-status,
  .experiment-result-header,
  .experiment-evidence-guidance > div { align-items: flex-start; flex-direction: column; }
  .literature-catalog-card { grid-template-columns: 48px minmax(0, 1fr); gap: 10px; }
  .training-readiness-metrics { grid-template-columns: 1fr; }
  .training-readiness-metrics span { border-right: 0; border-bottom: 1px solid rgba(133, 171, 233, .14); }
  .training-readiness-metrics span:last-child { border-bottom: 0; }
}